The co-use of conventional drug and herbal medicines may lead to Lifestyle herb-drug interaction via modulation of drug-metabolizing enzymes (DMEs) by herbal constituents.UDP-glucuronosyltransferases (UGTs) catalyzing glucuronidation are the major metabolic enzymes of Phase II DMEs.The in vitro inhibitory effect of several herbal constituents on on
RNA interference targeting NOX4 protects visual function in an experimental model of retinal detachment by alleviating blood-retinal barrier damage
AIM: To observe the effects of the inhibition of NADPH oxidase 4 (NOX4) expression on the retinal vascular barriers and visual function after retinal detachment (RD).METHODS: RD model was established 3wk after adeno-associaned virus vector injection.The retinal tissue was harvested 3d after RD, and the death of retinal vascular endothelial cells an
Dimensionality reduction bistatic radar clutter suppression technique based on three-dimensional cross-beam
Aiming at the problem that the non-stationary of airborne bistatic radar clutter reduces the performance of traditional clutter suppression algorithm, this paper first formulates airborne bistatic radar clutter model, and then analyzes the bistatic radar clutter characteristics in four typical combat scenarios.In addition, in order to reduce the co
Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes during development and throughout adulthood.This versatility is likely facilitated by the ability of Eph receptors to signal through diverse cellular signalling pathways: primarily by controlling cytoskeletal dynamics, but also by regulating cellular growth, p